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pentobarbital will lessen the extent or outcome of abiraterone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.Barbiturates can induce hepatic microsomal enzymes leading to enhanced metabolism and lessened anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); p